| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6062277 | Journal of Allergy and Clinical Immunology | 2016 | 15 Pages |
Abstract
In 2 distinct cohorts we have identified and replicated 6 clinicopathobiologic clusters based on blood and induced sputum measures. Our data underline a disconnect between clinical features and underlying inflammation, suggest IL-5 production is relatively steroid insensitive, and highlight the expression of YKL-40 in patients with neutrophilic inflammation and the expression of MMPs in patients with severe asthma.
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Authors
Timothy S.C. MD, Tom MD, Laurie C.K. PhD, Hitasha MD, Clair BSc, Scott BSc, Jon A. BSc, Junya BSc, Shoichiro MD, Kenji MD, Ratko MD, Ramesh J. MD, Anoop MD, Peter H. MD,