Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6062299 | Journal of Allergy and Clinical Immunology | 2016 | 18 Pages |
Abstract
APDS2 is a combined immunodeficiency with a variable clinical phenotype. Complications are frequent, such as severe bacterial and viral infections, lymphoproliferation, and lymphoma similar to APDS1/PASLI-CD. Immunoglobulin replacement therapy, rapamycin, and, likely in the near future, selective phosphoinositide 3-kinase δ inhibitors are possible treatment options.
Keywords
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Authors
Elodie MD, Benedicte MD, PhD, Julie MD, PhD, Kanako MD, Aurelie MSc, Lucie MSc, Carrie L. PhD, Helen BSc, Marie-Céline MSc, Svetlana PhD, James BSc, Janine MD, Catherine MD, David A. PhD, Gururaj FRCPath, PhD, Elizabeth MD, Sara Sebnem MD, Motoi MD,