| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6062300 | Journal of Allergy and Clinical Immunology | 2016 | 19 Pages |
Abstract
Persistent chronic inflammation in patients with CGD is associated with hematopoietic proliferative stress, leading to a decrease in the functional activity of HSCs. Our observations have clinical implications for the development of successful autologous cell therapy approaches.
Keywords
GMPX-linked chronic granulomatous diseaseCRULSKTPOCGDMNCIL-1βCMPHSCMEPeGFP5-FUCFUHPCMYD885-bromo-2′-deoxyuridineanakinraBrdUchronic granulomatous diseaseThrombopoietinPeripheral bloodHematopoietic stem cellmononuclear cellHematopoietic progenitor cellgranulocyte colony-stimulating factorG-CSF5-fluorouracilbone marrowwild-typecolony-forming unitenhanced green fluorescent proteincommon myeloid progenitorCell cycleGene therapy
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Authors
Maren PhD, Uta M. MSc, Stefan PhD, Linping PhD, Fabien MD, PhD, Giorgia PhD, Stefanie MSc, Christian PhD, Ulrich PhD, Marina MD, PhD, Adrian J. MD, PhD, Janine MD, Marieke A.G. PhD, Joachim MD, Manuel PhD,