Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6062305 | Journal of Allergy and Clinical Immunology | 2016 | 25 Pages |
Abstract
This study identifies the TRPV4-ATP-P2X3 interaction as a key osmosensing pathway involved in airway sensory nerve reflexes. The absence of TRPV4-ATP-mediated effects on C-fibers indicates a distinct neurobiology for this ion channel and implicates TRPV4 as a novel therapeutic target for neuronal hyperresponsiveness in the airways and symptoms, such as cough.
Keywords
4α-PDDTrpNCBIαβ-meATPRARTRPV4αβ-methylene-ATPAUCDiIDMSOECs[Ca2+]iATPSensory nervesCOPDChronic obstructive pulmonary diseaseDimethyl sulfoxideextracellular solutionConduction velocityCoughNational Center for Biotechnology Informationarea under the curveHypotonicityVagusPannexin 1transient receptor potentialIon channelsintracellular free calcium
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Authors
Sara J. PhD, Mark A. PhD, Megan S. PhD, Sarah A. PhD, John J. PhD, Michael A. PhD, Eric PhD, Yee-Man MRes, Anthony P. PhD, Fisnik MD, Montserrat PhD, Gema PhD, Jaclyn A. PhD, Maria G. PhD,