| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6062377 | Journal of Allergy and Clinical Immunology | 2016 | 33 Pages |
Abstract
The pruritus- and TH2-associated novel cytokine IL-31 induces a distinct transcriptional program in sensory neurons, leading to nerve elongation and branching both in vitro and in vivo. This finding might help us understand the clinical observation that patients with atopic dermatitis experience increased sensitivity to minimal stimuli inducing sustained itch.
Keywords
PI3KTRPV1DRGRNA-seqIPAERKtrkAPGP9.5STAT3NGFtropomyosin receptor kinase AIL-31Ingenuity Pathway AnalysisTransgenicRNA sequencingAtopic dermatitisnerve growth nerve growth factorphosphoinositide 3-kinasesignal transducer and activator of transcription 3protein gene product 9.5extracellular signal-regulated kinasedorsal root ganglia
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Authors
Micha PhD, Richard PhD, Jörg PhD, Shintaro PhD, Katherine PhD, Gareth MSc, Peter PhD, Kristin MSc, Holger MSc, Kaarel PhD, Olga PhD, Hans Werner PhD, Sophia PhD, Juha MD, PhD, Stacey R. PhD, Martin MD, PhD, Bernhard MD,