Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6062592 | Journal of Allergy and Clinical Immunology | 2016 | 16 Pages |
Abstract
We found impaired nasal epithelial barrier function in patients with HDM-induced AR, with lower occludin and zonula occludens-1 expression. IL-4 disrupted epithelial integrity in vitro, and FP restored barrier function. Better understanding of nasal barrier regulation might lead to a better understanding and treatment of AR.
Keywords
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Immunology
Authors
Brecht MSc, Ricard PhD, Paulina MSc, Jochen MSc, Emily MSc, Hanne PhD, Laura MD, PhD, Inge MSc, Dominique M.A. MD, PhD, Jan L. MD, PhD, Cezmi A. MD, Guy MD, PhD, Sven F. PhD, Peter W. MD, PhD,