Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6062637 | Journal of Allergy and Clinical Immunology | 2016 | 10 Pages |
Abstract
Pharmacologically resetting the molecular clock in mast cells or basophils to times when FcεRI signaling is reduced can inhibit IgE-mediated allergic reactions. The results suggest a new strategy for controlling IgE-mediated allergic diseases. Additionally, this study suggests a novel mechanism underlying the antiallergic actions of glucocorticoids that relies on the circadian clock, which might provide a novel insight into the pharmacology of this drug in allergic patients.
Keywords
DEXIgEBMMCbrain and muscle ARNT-like 1OVACryptochromeSCNcyclic AMPBmal1cAMPPCAAllergyPassive cutaneous anaphylaxisOvalbuminbasophilsperPeriodDexamethasoneZeitgeber timeClockCircadian ClockBone marrow–derived mast cellMast cellsSuprachiasmatic nucleuscircadian locomotor output cycles kaputcasein kinaseJapanese cedar pollenCry
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Authors
Yuki PhD, Nobuhiro PhD, Kayoko Ishimaru, Noriko MD, Ryohei MD, PhD, Katsue MD, PhD, Satoru PhD, Hideoki MD, PhD, Ko MD, PhD, Shigenobu PhD, Atsuhito MD, PhD,