| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6062707 | Journal of Allergy and Clinical Immunology | 2016 | 19 Pages |
Abstract
Defective production of GM-CSF leads to insufficient post-AAI rAM maturation in mice that recovered from an AAI, causing increased susceptibility to RSV-induced immunopathology. Promoting the differentiation of post-AAI rAMs might be a therapeutic option for preventing RSV-induced exacerbations in human asthmatic patients.
Keywords
GM-CSFDulbecco Modified Eagle MediumPFABALIRFHBSSRSVOVAAAITLRSiglec-FNF-κBDMEMAHRAllergic asthmaAllergic airway inflammationOvalbuminAirway hyperreactivityToll-like receptorRoom temperatureRamDendritic cellinterferon regulatory factornuclear factor κBphycoerythrinbronchoalveolar lavageAlveolar macrophageplaque-forming unitsRespiratory syncytial virusparaformaldehydepfu
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Authors
Thomas PhD, Bert PhD, Muriel PhD, Charlotte PhD, Lien MSc, Ans MSc, Monique PhD, Bart MD, PhD, Stefaan PhD, Xavier PhD, Johan PhD,