| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6062719 | Journal of Allergy and Clinical Immunology | 2016 | 12 Pages |
Abstract
The 17q12-21 locus has a strong genetic association with allergic asthma but not with AR. The polymorphic effect of this locus is attributed to the linkage set tagged by rs8076131, which affects the expression of ORMDL3, protein phosphatase 1, regulatory inhibitor subunit 1B (PPP1R1B), zona pellucida binding protein 2 (ZPBP2), and gasdermin B (GSDMB) and is correlated with high IgE levels and eosinophil counts in subjects bearing the risk genotype.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Anand Kumar PhD, Yang Yie BSc, Bernett PhD, Bani Kaur PhD, Sri Anusha BTech, Josephine BSc, Shihui BSc, Geraldine BSc, Jianjun PhD, Francesca PhD, Michael PhD, De Yun MD, PhD, Olaf PhD, Fook Tim PhD,