| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6062720 | Journal of Allergy and Clinical Immunology | 2016 | 13 Pages |
Abstract
FXIII expression was upregulated in the airways of asthmatic patients after allergen exposure. Expression in the sputum of asthmatic patients correlated with the type 2 immune response and airflow limitation. Excessive activity of FXIII could contribute to the pathophysiology of airway obstruction in asthmatic patients.
Keywords
qPCRDendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrinSARPcoagulation factor XIIIIL-13DC-SIGNBALFVCTLCQuantitative PCRFXIIIcycle thresholdAsthmaSevere asthmaAllergyEosinophilsinflammationAirway obstructionSevere Asthma Research ProgramAir trappingResidual volumereverse transcriptionDendritic cellforced vital capacityTotal lung capacityPulmonary functionFactor XIIIbronchoalveolar lavage
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Authors
Stephane PhD, Elizabeth A. PhD, Ronald L. PhD, Michael D. MS, William W. MD, Nizar N. MD,