Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6063017 | Journal of Allergy and Clinical Immunology | 2015 | 16 Pages |
Abstract
This is the first randomized placebo-controlled trial evaluating the novel coadministration of a probiotic and peanut OIT and assessing sustained unresponsiveness in children with peanut allergy. PPOIT was effective in inducing possible sustained unresponsiveness and immune changes that suggest modulation of the peanut-specific immune response. Further work is required to confirm sustained unresponsiveness after a longer period of secondary peanut elimination and to clarify the relative contributions of probiotics versus OIT.
Keywords
SPTDBPCFCSAERCTPeanut-specific IgENNTRCHIQRSpecific IgG4NIAIDFDASpecific IgERandomized controlled trialpeanut allergyUS Food and Drug Administrationoral immunotherapySkin prick testToleranceOITnumber needed to treatadverse eventsustained unresponsivenessSerious adverse eventinterquartile rangeNational Institute of Allergy and Infectious DiseasesRisk ratioodds ratioProbioticDouble-blind, placebo-controlled food challengeDesensitizationsIgE
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Authors
Mimi L.K. PhD, Anne-Louise PhD, Francesca MSc, Dean FRACP, Marnie FRACP, Ee Lyn FRACP, Paul PhD, Wesley MD, Susan MA,