IL-10/Janus kinase/signal transducer and activator ofÂ transcription 3 signaling dysregulates Bim expression inÂ autoimmune lymphoproliferative syndrome

Article ID	Journal	Published Year	Pages	File Type
6063020	Journal of Allergy and Clinical Immunology	2015	9 Pages	PDF

Abstract

Combined, these data show that an IL-10/Janus kinase/signal transducer and activator of transcription 3 pathway drives Bim expression in ALPS DNTC, which renders them sensitive to BH3 mimetics, uncovering a potentially novel therapeutic approach to ALPS.

Keywords

NF-κB ABT-737 IL-10R IL-10 receptor IL-10 TCr BH3 mimetic CDR LPR MFI Janus kinase STAT Apoptosis Double negative T cells Alps autoimmune lymphoproliferative syndrome nuclear factor-κB Lymphoproliferative Signal transducer and activator of transcription BIM complementarity determining region mean fluorescence intensity T cell homeostasis JAK T cell receptor