Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6063050 | Journal of Allergy and Clinical Immunology | 2014 | 7 Pages |
Abstract
In the United States the economically disadvantaged and some ethnic minorities are often exposed to chronic psychosocial stressors and disproportionately affected by asthma. Current evidence suggests a causal association between chronic psychosocial stress and asthma or asthma morbidity. Recent findings suggest potential mechanisms underlying this association, including changes in the methylation and expression of genes that regulate behavioral, autonomic, neuroendocrine, and immunologic responses to stress. There is also evidence suggesting the existence of susceptibility genes that predispose chronically stressed youth to both post-traumatic stress disorder and asthma. In this review we critically examine published evidence and suggest future directions for research in this field.
Keywords
PACAPCRHAORAsthmaSESpost-traumatic stress disorderPTSDPsychosocial stressmaternal separationImmune systemAutonomic nervous systemANSNeuroendocrine systemHPAadjusted odds ratiocorticotropin-releasing hormonehypothalamic-pituitary-adrenocorticalsocioeconomic statusPituitary adenylate cyclase–activating polypeptideSingle nucleotide polymorphismSNPGenetics
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Authors
Stacy L. MD, Gregory E. PhD, John M. MD, MPH, Juan C. MD, DrPH,