Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease

Article ID	Journal	Published Year	Pages	File Type
6063352	Journal of Allergy and Clinical Immunology	2015	27 Pages	PDF

Abstract

Subsets of airway MDRCs conclusively discriminate patients with mild asthma, patients with COPD, and healthy subjects from each other. The distinctive activities of these MDRCs in patients with asthma or COPDÂ might provide novel targets for new therapeutics for these common disorders.

Keywords

iNOS DAF-FM-DA nor-NOHA MDSC UAB phorbol 12-myristate 13-acetate BAL RNS DPI NADPH FACS natural killer 4-Amino-5-Methylamino-2′,7′-Difluorofluorescein Diacetate PMA PCA ROS Chronic obstructive pulmonary disease COPD Principal component analysis University of Alabama at Birmingham fluorescence-activated cell sorting Diphenyleneiodonium SOD Regulatory T cell Myeloid cell myeloid-derived suppressor cell inducible nitric oxide synthase Superoxide Superoxide dismutase body mass index BMI bronchoalveolar lavage Macrophage Nitric oxide nicotinamide adenine dinucleotide phosphate DHE reactive nitrogen species Reactive oxygen species