| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6063462 | Journal of Allergy and Clinical Immunology | 2015 | 25 Pages |
Abstract
Polymorphisms in a putative promoter region of ORMDL3, which are associated with childhood asthma, alter transcriptional regulation of ORMDL3, correlate with changes in TH2 cytokines levels, and therefore might contribute to the childhood asthma susceptibility signal from 17q21.
Keywords
LPAphorbol 12-myristate 13-acetatePPGSPTUSFORMDL3PMAElectrophoretic mobility shift assaycycle thresholdAsthmaSkin prick testTranscriptional regulationExact EMSA یا electrophoretic mobility shift assay Th2 cytokineLinkage disequilibriumUpstream stimulatory factorPromoter activityLipid AAssociation studyGenome-wide association studyGWASUTR یا untranslated regions untranslated regionodds ratiospecificity proteinPolymorphismSingle nucleotide polymorphismPeptidoglycanSNP
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Authors
Michaela PhD, Sven PhD, Vincent D. BSc, Antoaneta A. PhD, Martin PhD, Aristea PhD, Maximilian PhD, Marie T. MD, Norman PhD, Andrea MD, Albrecht MD, Otto MD, Ernst MD, Andrea MD, Burkard MD, Christian MD, Jon MD, Thomas PhD, Michael MD,