| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6063594 | Journal of Allergy and Clinical Immunology | 2016 | 9 Pages |
Abstract
In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor. We posit that its production during allergen-induced memory responses contributes significantly to attenuation of inflammation through promoting IgG1-mediated damping of the FcεRI-dependent acute-phase reaction. sIgG1/sIgE balance might represent a readily accessible therapeutic target for asthma/rhinitis control.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Patrick G. DSc, FAA, Deborah PhD, Anthony PhD, Danielle MD, PhD, Belinda PhD, Angela MD, PhD, Elysia PhD, Barbara BSc, Merci MBBS, Staffan PhD, Peter D. FRCP, DSc, Adnan MD, PhD,