| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6063766 | Journal of Allergy and Clinical Immunology | 2015 | 23 Pages |
Abstract
We describe a novel mechanism explaining interferon deficiency in asthmatic patients through a novel nuclear function of SOCS1 and identify SOCS1 as an important therapeutic target for asthma exacerbations.
Keywords
NF-κBBECGFPLIXSOCSBALCytokine-inducible SH2-containing proteinTH2 inflammationISRENLSISGPolyI:CAtopyAsthmaatopic asthmaSTATInnate immunityinterferonAsthma exacerbationnuclear localization sequencesuppressor of cytokine signalingBronchial epithelial cellCytokineinterferon-stimulated response elementnuclear factor κBbronchoalveolar lavageSignal transducer and activator of transcriptionNanARhinovirusgreen fluorescent proteinpolyinosinic-polycytidylic acidinterferon-stimulated genestrAKeratinocyte-derived chemokineCISH
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Authors
Vera MSc, Annemarie MD, Jie PhD, Brian BSc, Jonathan MD, Nicolas MD, Elisabeth MD, Atul MD, PhD, Amelia PhD, Cara MD, Jane MD, PhD, Sejal MD, PhD, Patrick PhD, Sandra E. PhD, Alexander H. MD, PhD, Onn-Min MD, PhD, Andrew MD, PhD, Sebastian L. MD, PhD,