| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6063857 | Journal of Allergy and Clinical Immunology | 2013 | 9 Pages |
Abstract
TCR ligation causes WASP to be degraded by calpain and to be ubiquitinated by Cbl family E3 ligases, which targets it for destruction by the proteasome. WASP degradation might provide a mechanism for regulating WASP-dependent TCR-driven assembly of F-actin.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Yuko MD, PhD, Yoji MD, PhD, Narayanaswamy PhD, Michel J. PhD, Chung PhD, Satoru MD, PhD, Shigeo MD, PhD, Raif S. MD, Shigeru MD, PhD,