| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6064079 | Journal of Allergy and Clinical Immunology | 2015 | 14 Pages |
Abstract
Our findings demonstrate a critical role of SIRT1 in skin barrier maintenance, open up new opportunities to use SIRT1 as a pharmacologic target, and might facilitate the development of mechanism-based agents for AD prevention and therapy.
Keywords
FLGcKOARNTsirtuin 1OVABAPTEWLCYP1B1XRENHEKMEFK10AHRSirtuin 1 (SIRT1)NF-κBEGFRSirt1Small interfering RNAsiRNAaryl hydrocarbon receptor nuclear translocatorTransepidermal water lossOvalbuminBenzo(a)pyreneAtopic dermatitisxenobiotic response elementnuclear factor κBfilaggrinskin barriermouse embryonic fibroblastknockoutwild-typekeratin 10Normal human epidermal keratinocytenegative controlaryl hydrocarbon receptorEpidermal growth factor receptor
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Authors
Mei PhD, Baozhong PhD, Christopher R. MD, Palak MB, Lei PhD, Steven R. MD, Diane M. BS, Yu-Ying PhD,