Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteinsâ

Article ID	Journal	Published Year	Pages	File Type
6064195	Journal of Allergy and Clinical Immunology	2015	9 Pages	PDF

Abstract

Component-resolved diagnostics help to distinguish between sensitization caused by occupational flour exposure and wheat seropositivity based on cross-reactivity to grass pollen. For routine diagnosis of baker's allergy, however, allergen-specific IgE tests with whole wheat and rye flour extracts remain mandatory because of superior diagnostic sensitivity.

Keywords

Alpha-amylase inhibitor HRP CCD ROC nsLTP MBP GAPDH AUC Specific IgE Allergen-specific IgE Rye flour Baker's asthma recombinant allergens Wheat allergy component-resolved diagnosis Cross-reactive carbohydrate determinant area under the curve Cross-reactivity Horseradish peroxidase nonspecific lipid transfer protein maltose-binding protein Grass pollen sIgE glyceraldehyde-3-phosphate dehydrogenase Triticum aestivum receiver operating characteristic