| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6064215 | Journal of Allergy and Clinical Immunology | 2015 | 16 Pages |
Abstract
These results unveil not only a novel function of PPARβ/δ as a direct regulator of acute vessel permeability and dilatation but also provide evidence that antagonizing PPARβ/δ represents an important strategy to consider for moderating diseases with altered endothelial integrity, such as acute inflammatory and allergic disorders.
Keywords
HUVECVSMCVEGF-AEBDVEGFRAVHDAPIBMMCPPARERKGAPDHPeroxisome proliferator-activated receptor β/δ4′-6-diamidino-2-phenylindole dihydrochlorideSmall interfering RNAsiRNAAnaphylaxissmooth muscle actinEndotheliumSMAEvans Blue dyeHuman umbilical vein endothelial cellVascular smooth muscle cellSmooth muscle cellsBone marrow–derived mast cellVascular endothelial growth factor AVascular permeabilityNitric oxideadherens junctionsextracellular signal-regulated kinaseglyceraldehyde-3-phosphate dehydrogenasevascular endothelial growth factor receptorperoxisome proliferator-activated receptor
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Marta PhD, Christine PhD, Barbara PhD, Frédéric PhD, Sébastien BSc, Sandrine MSc, Marie MSc, Emmanuel Bouchaert, Catherine Moret, Lionel Mury, Corinne Rommens, Hélène Mottaz, David PhD, Liliane PhD,