| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6064386 | Journal of Allergy and Clinical Immunology | 2014 | 11 Pages |
Abstract
A sputum gene expression signature of 6 biomarkers reproducibly and significantly discriminates inflammatory phenotypes of asthma and predicts ICS treatment response. This signature has the potential to become a useful diagnostic tool to assist in the clinical diagnosis and management of asthma.
Keywords
CPA3IRAK2FeNOTNFRSF1BCXCR1ΔCTIL1R2NLRP3PI3ISG20chemokine (C-X-C motif) receptor 2carboxypeptidase A3TNFAIP3Cathelicidin antimicrobial peptideIL1bMGAORM1FPR2GBP1IL1RNIL-1βDEFB1NLR family, pyrin domain containing 3TFF3qPCRPGACLCNFKB2BIRC3PLAUACQICSALPLNAMPTTNFSF14HDCCCR7CXCR2AUCcAMPAsthmaEosinophilic asthmaneutrophilic asthmaIL-1 receptor antagonistEosinophilsGene expressionFraction of exhaled nitric oxidearea under the curveinduced sputumNeutrophilsnicotinamide phosphoribosyltransferaseHistidine Decarboxylasequantitative real-time PCRAsthma Control QuestionnaireInhaled corticosteroidformyl peptide receptor 2
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Authors
Katherine J. PhD, Jodie L. PhD, Lisa G. PhD, Rodney J. PhD, Naomi L. DipPathTech, Heather MMedSci, Douglas C. PhD, D. Robin DSc, Jan O. Cowan, Peter G. MBBS,