| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6064437 | Journal of Allergy and Clinical Immunology | 2014 | 21 Pages |
Abstract
This study highlights the selective expression of Cav1.2 channels in human TH2 cells and the role of PKC-dependent Cav1.2 channel activation in TH2 cell function. Blocking PKC or Cav1.2 channel activation in TH2 cells might represent new strategies to treat allergic diseases in human subjects.
Keywords
NFATCAV1[Ca]iCFSEphorbol 12-myristate 13-acetateCRTH2PKColigodeoxynucleotideODNqPCRFITCTCrPMAQuantitative PCRAsthmaAntisenseTH2 cytokinesendoplasmic reticulumNuclear Factor of Activated T Cellsintracellular calcium concentrationphycoerythrinfluorescein isothiocyanatechemoattractant receptor-homologous molecule expressed on Th2 cellsProtein kinase CVoltage-dependent calcium channelscarboxyfluorescein succinimidyl esterCalciumT-cell receptor
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Authors
Virginie PhD, Emily PhD, Pierre-Emmanuel BSc, Jean-Charles PhD, Lucette MD, PhD, Magali PhD,