Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6064535 | Journal of Allergy and Clinical Immunology | 2015 | 20 Pages |
Abstract
This study provides mechanistic evidence that IL-10 creates a chromatin environment that decreases the transcriptional rate of CXCL8 and TNF-α to Toll-like receptor 4-activating signals. Data identify novel molecular targets for therapeutic strategies aimed at dampening inflammation in pathologies such as chronic obstructive pulmonary disease, in which reduced intracellular HDAC2 levels have been described.
Keywords
HDACPRLCBPARFIL-10CXCL8CDK9NF-κBGAPDHMIPqPCRTLRSTATchromatin immunoprecipitationCOPDChronic obstructive pulmonary diseaseToll-like receptorTNF-αnuclear factor κBSignal transducer and activator of transcriptionTranscriptional inhibitionAcute respiratory failureHistone acetyltransferasehistone deacetylaseHistone deacetylase 2quantitative real-time PCRCREB-binding proteinmacrophage inflammatory proteinProlactinPol IIpolymerase IICHiPHATCyclin-dependent kinase 9glyceraldehyde-3-phosphate dehydrogenase
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Monica PhD, Marzia PhD, Federica BS, Nicola PhD, Stefano MD, Marco A. MD, Flavia PhD,