Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6064627 | Journal of Allergy and Clinical Immunology | 2014 | 9 Pages |
Abstract
This is the first report that exploits next-generation sequencing to determine local and peripheral blood IGH repertoires in patients with respiratory allergic disease. We demonstrate that natural pollen exposure was associated with changes in IgE repertoires that were suggestive of ongoing germinal center reactions. Furthermore, these changes were more often apparent in nasal biopsy specimens compared with peripheral blood and in patients with AR compared with healthy control subjects.
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Authors
Yu-Chang B. PhD, Louisa K. PhD, Jason A. MSc, Mohamed PhD, Stephen R. MD, FRCP, Steven H. PhD, David DPhil, Hannah J. PhD,