Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6064647 | Journal of Allergy and Clinical Immunology | 2014 | 9 Pages |
Abstract
Clonally expanded CD19+CD27+CD20âCD38hi plasmablasts are a hallmark of active IgG4-RD. Enhanced somatic mutation in activated B cells and plasmablasts and emergence of distinct plasmablast clones on relapse indicate that the disease pathogenesis is linked to de novo recruitment of naive B cells into T cell-dependent responses by CD4+ T cells, likely driving a self-reactive disease process.
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Authors
Hamid PhD, Vinay S. MBBS, PhD, Emanuel MD, Yurie BS, Mollie MD, Zachary S. MD, Vikram MD, John H. MD, MPH, Shiv MBBS, PhD,