Article ID Journal Published Year Pages File Type
6064647 Journal of Allergy and Clinical Immunology 2014 9 Pages PDF
Abstract
Clonally expanded CD19+CD27+CD20−CD38hi plasmablasts are a hallmark of active IgG4-RD. Enhanced somatic mutation in activated B cells and plasmablasts and emergence of distinct plasmablast clones on relapse indicate that the disease pathogenesis is linked to de novo recruitment of naive B cells into T cell-dependent responses by CD4+ T cells, likely driving a self-reactive disease process.
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