| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6064715 | Journal of Allergy and Clinical Immunology | 2015 | 19 Pages |
Abstract
IL-13 treatment of HAECs leads to β2AR desensitization, which involves 15LO1/PEBP1 interactions to free GRK2, and allows it to phosphorylate (and desensitize) β2ARs, suggesting that the beneficial effects of β2-agonists could be blunted in patients with type 2 associated asthma.
Keywords
ALOX1515-lipoxygenase-1PEBP1GAPDHphosphatidylethanolamine-binding protein 1IL-13ERKGRK2GCVarachidonate 15-lipoxygenaseSABAGPCRICSβ2ARcAMPG protein–coupled receptorshort interfering RNAsiRNAAsthmaLong-acting β2-agonistAliISOImmunofluorescenceHAECShort-acting β-agonistImmunoprecipitationLABAHealthy control subjectair-liquid InterfaceInhaled corticosteroidextracellular signal-regulated kinaseglyceraldehyde-3-phosphate dehydrogenaseβ2-adrenergic receptor
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Authors
Giusy D. PhD, Jinming PhD, Emily B. BS, Seo Young PhD, Haizhen BS, John B. BS, Mirella PhD, Sally E. MD,