Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6064734 | Journal of Allergy and Clinical Immunology | 2015 | 10 Pages |
Abstract
This is the first report of a lesional AD phenotype using RNA-seq and the first direct comparison between platforms in this disease. Both platforms robustly characterize the AD transcriptome. Through RNA-seq, we unraveled novel disease pathology, including increased expression of the novel TREM-1 pathway and the IL-36 cytokine in patients with AD.
Keywords
K16MicroarraysLCETREM-1FDRRNA-seqFCHTLRRT-PCRReal-time PCRCSAIHCImmunohistochemistryRNA sequencingfold changeToll-like receptorAtopic dermatitiscyclosporin ADEGfalse discovery rateMicro-RNAMiRNAlate cornified envelopeDifferentially expressed genekeratin 16Triggering Receptor Expressed on Myeloid cells 1
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Authors
Mayte PhD, Benjamin BA, Joel PhD, David A. MSc, Mariya BA, Juana PhD, Hui MSc, Xiuzhong MSc, Xiangyu MSc, Yeriel D. MSc, Stacey R. PhD, James G. MD, PhD, Emma MD, PhD,