| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6064972 | Journal of Allergy and Clinical Immunology | 2015 | 11 Pages |
Abstract
The evidence for a role for TH17 cells in patients with severe asthma is limited. Severe asthma is associated with a striking deficiency of MAIT cells and high mast cell mediator levels. This study provides proof of concept for disease mechanistic networks in asthmatic patients with clusters that could inform the development of new therapies.
Keywords
Th17Mucosal-associated invariant TBNATDATh2cytotoxic TTregICSACQeNOIQRFOXP3BALendotypeAsthmaexhaled nitric oxideTopological data analysisBayesian network analysisCytokinesGlobal Initiative for AsthmaPhenotypebronchoalveolar lavageT lymphocytesMast cellsinterquartile rangeRegulatory T MAITAsthma Control Questionnaireforkhead box protein 3Inhaled corticosteroidGINA
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Authors
Timothy S.C. MD, Xiaoying PhD, Karl J. PhD, Borislav D. MD, Alexander PhD, Tanya PhD, Pek Y. PhD, Caroline G. RN, Jon A. BSc, Peter H. MD, Andrew F. PhD, Stephan D. MD, Ratko MD,