| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6065122 | Journal of Allergy and Clinical Immunology | 2014 | 12 Pages |
Abstract
Our results support epistasis between SPINK5 and TSLP, which contributes to childhood asthma. These findings emphasize the importance of using biology to inform analyses to identify genetic susceptibility to complex diseases. The results from our study have clinical relevance and support that the therapeutic effects of anti-TSLP therapy in asthmatic patients might be dependent on SPINK5 genotype.
Keywords
Database of Genotypes and PhenotypesLEKTICCCdbGaPAncestry-informative markerKLKFLGTSLPCCAAPSGCCSPTcAMPChildhood asthmaGenetic associationCareEpistasisChildhood Asthma Management ProgramChildhood Asthma Research and EducationSkin prick testAtopic dermatitisLinkage disequilibriumfilaggrinThymic stromal lymphopoietinCincinnati Childhood Allergy and Air Pollution StudyGenome-wide association studyGWASprincipal componentodds ratioAIMSingle nucleotide polymorphismkallikrein-related peptidaseSNP
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Authors
Jocelyn M. PhD, Lisa J. PhD, Melinda Butsch MPH, PhD, Tesfaye B. PhD, Hua MS, Valentina PhD, Mark A. BS, Mark B. MS, David I. MD, Grace K. PhD, James E. MD, Gurjit K. MD, PhD,