Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6065144 | Journal of Allergy and Clinical Immunology | 2014 | 24 Pages |
Abstract
Unconditioned URD HCT achieves excellent rates of donor T-cell engraftment similar to that seen in MSD recipients, and reconstitution rates are adequate. However, only a minority will have myeloid and B-cell reconstitution, and attention must be paid to graft-versus-host disease prophylaxis. This approach might be safer in children ineligible for intense regimens to spare the potential complications of chemotherapy.
Keywords
RAGURDGvHDTotal nucleated cellPIDTCJanus kinase 3IL2RGJAK3LIG4cGVHDaGVHDTRMUCBTNCSCIDEFsHCTMSDadenosine deaminaseUnrelated donorUnrelated donorsEvent-free survivaloverall survivalAcute graft-versus-host diseaseGraft-versus-host diseaseChronic graft-versus-host diseaseUmbilical cord bloodSerotherapyConditioningTransplant-related mortalitybone marrowSCID, Severe combined immunodeficiencyADAHematopoietic cell transplantationRecombination-Activating Gene
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Authors
Christopher C. MD, Amel MD, Mary A. MD, Manfred MD, Arjan C. MD, Rebecca H. MD, Michael A. MD, Jeffrey H. MD, Tayfun MD, Melissa MD, Jacob H. MD, Nancy MD, Petr MD, James A. MD, David F. MD, PhD, Luigi D. MD, Sung-Yun MD, Jake BS, Morton J. MD,