| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6065146 | Journal of Allergy and Clinical Immunology | 2014 | 19 Pages |
Abstract
We identify a novel tolerogenic circuit encompassing suppressive CD1c+ DCs and regulatory T cells in patients with COPD that might be implicated in impaired respiratory immunity and further highlight IL-10 and IL-27 as potent therapeutic targets.
Keywords
CFSEinducible costimulator ligandILT4IL-10 receptorIL-10Rinducible T-cell costimulatorICOSTBX21RORCSLPIIL-27TregIL-10BALAPCAHRFOXP3PD-1PD-L1GAPDHMAFTCMantigen-presenting cellneutrophil elastaseCOPDChronic obstructive pulmonary diseaseDendritic cellDendritic cellsRegulatory T cellsConditioned mediumbronchoalveolar lavageProgrammed death ligand 1Tissue culture mediumprogrammed cell death 1Regulatory T secretory leukocyte protease inhibitorforkhead box protein 3carboxyfluorescein succinimidyl esterglyceraldehyde-3-phosphate dehydrogenasearyl hydrocarbon receptor
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Authors
Maria MD, PhD, Sofia MD, Maria PhD, Panagiota MD, Anna MD, Ioannis PhD, Eleni PhD, Aikaterini I. MSc, Maria MSc, Konstantinos MD, PhD, Joseph MD, PhD, Patrick MD, PhD, Spyros MD, PhD, Sebastian L. MD, PhD, Georgina PhD,