| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6065221 | Journal of Allergy and Clinical Immunology | 2013 | 17 Pages |
Abstract
RV-16 infection of human airway epithelium induces glucocorticoid resistance. Inhibition of RV-16-induced JNK and nuclear factor κB activation fully reversed rhinovirus impairment of both GRα nuclear translocation and the transactivation/transrepression activities of glucocorticoids.
Keywords
NF-κBRhinovirus 16HBECviral respiratory tract infectionsMKP-1EmaxIKKICSGREEC50ICAM-1JnkGAPDHc-Jun N-terminal kinaseIκB kinaseMOISmall interfering RNAsiRNAAsthmaHuman bronchial epithelial cellGlucocorticoid response elementTranscription factorsnuclear factor κBmedian effective concentrationIntercellular adhesion molecule 1mitogen-activated protein kinase Phosphatasemultiplicity of infectionInhaled corticosteroidKinasesGlucocorticoidsglyceraldehyde-3-phosphate dehydrogenaseglucocorticoid receptor
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Alberto MD, Marco MD, Ian M. PhD, Cinzia PhD, Anna BS, Paolo PhD, Luminita A. PhD, Peter J. MD, Sebastian L. MD, Kazuhiro PhD, Gaetano MD,