| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6065359 | Journal of Allergy and Clinical Immunology | 2014 | 18 Pages |
Abstract
For the first time, we have shown that tiotropium inhibits neuronal TRPV1-mediated effects through a mechanism unrelated to its anticholinergic activity. We speculate that some of the clinical benefit associated with taking tiotropium (eg, in symptom control) could be explained through this proposed mechanism of action.
Keywords
Long-acting muscarinic receptor antagonistURITrpPGE2RTXMCHDiIDMSOECsLAMA[Ca2+]iAnticholinergicsSensory nervesChronic obstructive pulmonary diseaseCOPDDimethyl sulfoxideextracellular solutionresiniferatoxinCoughUpper respiratory tract infectionMethacholineenhanced pauseVagustransient receptor potentialProstaglandin E2PenhIon channelsIntracellular calciumCapsaicin
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Authors
Mark A. PhD, Sara J. BSc, Eric PhD, Sarah A. PhD, Michael A. PhD, Megan S. PhD, Kristof PhD, John J. PhD, Maria G. PhD,