Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6065375 | Journal of Allergy and Clinical Immunology | 2014 | 10 Pages |
Abstract
The allergic rhinitis mucus proteome shows an enhanced immune response in which apolipoproteins might play an important role. Furthermore, an imbalance between cysteine proteases and antiproteases could be seen, which negatively affects epithelial integrity on exposure to pollen protease activity. This reflects the important role of mucus as the first-line defense barrier against allergens.
Keywords
α1-antitrypsinLysozyme CApoA2SERPINA1LTFVTnAPOA4Complement C5A2MSLPIWFDC2apoA1apoBLC-MS/MSα2-macroglobulinApolipoprotein A-1apolipoprotein B-100Complement C3Allergic rhinitisMass spectrometryLactotransferrinLYZNasal mucusHaptoglobinVitronectinProteomeProteomicsliquid chromatography–tandem mass spectrometrygranulinGRN
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Authors
Peter Valentin MD, Ruth PhD, Anita Leitner, Britta BSc, Stefan Spoerk, Doris MD,