| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6065524 | Journal of Allergy and Clinical Immunology | 2015 | 11 Pages |
Abstract
Novel immune-regulatory mechanisms in childhood asthma identified increased Treg cells in patients with AA compared with those in HCs but not those in NA and decreased innate immunity genes for patients with AA, the first potentially indicating a counterregulatory mechanism to suppress cytokines yet not sufficient to control allergic inflammation. Very distinctly, patients with NA showed an IL-17-shifted proinflammatory immunity, promoting neutrophil inflammation and less functional Treg cells. Identification of these unique pathways provides a profound basis for future strategies for individualized prediction of asthma development, disease course, and prevention.
Keywords
Tuberous sclerosis 1ILC2TregATSLPATSC1qRT-PCRERSCLIC4TREM1FOXP3eIF4Bquantitative real-time RT-PCRAllergic asthmaEuropean Respiratory SocietyAmerican Thoracic SocietyInnate immunityLinear discriminant analysisLDAforkhead box P3peripheral blood mononuclear cellsRegulatory T cellsLipid ATranscriptomicsRegulatory T Healthy control subjecttype 2 innate lymphoid cellTriggering Receptor Expressed on Myeloid cells 1
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Authors
Diana PhD, Nikolaus PhD, Elisabeth MD, Andreas PhD, Ragna MD, Olivia Prazeres da Costa, Otto PhD, Thomas PhD, Thorsten PhD, Erika MD, Bianca MD,