Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6065549 | Journal of Allergy and Clinical Immunology | 2015 | 11 Pages |
Abstract
This is the first report that establishes robust epidermal and dermal genomic signatures of lesional and nonlesional AD skin and normal skin compared with whole tissues. These data establish the utility of laser capture microdissection to separate different compartments and cellular subsets in patients with AD, allowing localization of key barrier or immune molecules and enabling detection of gene products usually not detected on arrays.
Keywords
EDCPI3FCHCTLA4ICOSFLGIL-34Granzyme BCSF-1RRT-PCRinducible T-cell costimulatorCLDNGZMBLCMSPRRFDRMx1Real-time PCRcytotoxic T-lymphocyte antigen 4LORTight junctionImmunefold changeAtopic dermatitisDendritic cellLangerhans cellDEGfilaggrinLoricrinlaser capture microdissectionBarrierEpidermal differentiation complexfalse discovery ratecornified envelopeSmall proline-rich proteinDifferentially expressed geneclaudincolony-stimulating factor 1 receptor
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Hitokazu MD, David A. MSc, Benjamin BA, Mariya BA, Xiuzhong MSc, Hui MSc, Yeriel D. BS, Xiangyu MSc, Hiroshi MD, PhD, Thomas PhD, Mayte PhD, James G. MD, PhD, Emma MD, PhD,