Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6065654 | Journal of Allergy and Clinical Immunology | 2013 | 23 Pages |
Abstract
Nuclear receptors are ligand-activated transcription factors linking lipid signaling to the expression of the genome. There is increasing appreciation of the involvement of this receptor network in the metabolic programming of macrophages and dendritic cells (DCs), essential members of the innate immune system. In this review we focus on the role of retinoid X receptor, retinoic acid receptor, peroxisome proliferator-associated receptor γ, liver X receptor, and vitamin D receptor in shaping the immune and metabolic functions of macrophages and DCs. We also provide an overview of the contribution of macrophage- and DC-expressed nuclear receptors to various immunopathologic conditions, such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, asthma, and some others. We suggest that systematic analyses of the roles of these receptors and their activating lipid ligands in immunopathologies combined with complementary and focused translational and clinical research will be crucial for the development of new therapies using the many molecules available to target nuclear receptors.
Keywords
15d-PGJ2PPARBALAP-1TLRABCRetinoid X receptorTregVDRLPALXRRARRXRTZDiNKToxLDLFDA9-cis-RAIBDMMPDBDLBDPDCGALT15-deoxy-Δ12,14-Prostaglandin J2atRAHODEcollagen-induced arthritisRheumatoid arthritisAsthmaSTATUS Food and Drug Administrationlysophosphatidic acidhydroxyoctadecadienoic acidall-trans-retinoic acidgut-associated lymphoid tissueInflammatory bowel diseaseThiazolidinedioneToll-like receptorDNA-Binding Domainligand-binding domainDendritic cellPlasmacytoid dendritic cellCIAinvariant natural killer Tbronchoalveolar lavageSystemic lupus erythematosusSLEOxidized low-density lipoproteinLipidmatrix metalloproteinaseMacrophageSignal transducer and activator of transcriptionRegulatory T activator protein 1liver X receptorATP-binding cassetteRetinoic acid receptorVitamin D receptorNuclear receptor
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Authors
Mate Kiss, Zsolt MSc, Laszlo MD, PhD,