Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6065688 | Journal of Allergy and Clinical Immunology | 2013 | 21 Pages |
Abstract
The IL-21R/STAT3 pathway is required for many aspects of human CD8+ T-cell behavior but in some cases can be compensated by other signals. This helps explain the relatively mild susceptibility to viral disease observed in STAT3- and IL-21R-deficient subjects.
Keywords
EomesoderminIL-21 receptorIL-21RAutosomal dominant hyper-IgE syndromeAD-HIESeffector memory TTEMRAIL-21LCMVBclTCMSTAT3CTVPIDTCrStat1STATTemDifferentiationMemoryPeripheral bloodEOMESB-cell lymphomaSignal transducer and activator of transcriptionLymphocytic choriomeningitis virusprimary immunodeficiencyT-cell receptor
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Authors
Megan L. BAdvSc, Cindy S. PhD, Umaimainthan PhD, Anna MSc, Jacinta MD, PhD, Stephanie PhD, Peter D. FRCPCH, DPhil, Dan MD, Diana MD, Klaus MD, Joachim MD, PhD, Jane MBBS, Melanie MBBS, PhD, FRCPA, Stephen MBBS, PhD, FRACP, FRCPA, Sharon MBBS, FRACP,