| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6065700 | Journal of Allergy and Clinical Immunology | 2013 | 9 Pages |
Abstract
In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.
Keywords
DPIEPX7AAD7-aminoactinomycin DJnkPFANaN3ERKHRPc-Jun N-terminal kinaseDUSPMAPKROSHydrogen peroxideSTATeosinophil peroxidaseEosinophilsdual-specificity phosphataseDiphenyleneiodoniumsodium azideSialic acid–binding immunoglobulin-like lectinSiglecSignalingSignal transducer and activator of transcriptionMEKCell deathH2O2paraformaldehydeHorseradish peroxidasemitogen-activated protein kinaseextracellular signal-regulated kinaseReactive oxygen species
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Authors
Gen MD, PhD, Maha MD, Bruce S. MD, Nives MD,