Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6065862 | Journal of Allergy and Clinical Immunology | 2014 | 22 Pages |
Abstract
IL-33 is a novel profibrogenic cytokine that signals through ST2 to promote the initiation and progression of pulmonary fibrosis by recruiting and directing inflammatory cell function and enhancing profibrogenic cytokine production in an ST2- and macrophage-dependent manner.
Keywords
APCNOS2IL-33BMDMARG1ILC2BALICOSIPFM1 macrophageFITCqPCRQuantitative PCRarginase 1allophycocyanincomputed tomographytype 2 innate lymphoid cellsphycoerythrinfluorescein isothiocyanateLung fibrosisidiopathic pulmonary fibrosisbronchoalveolar lavageM2 macrophageBone marrow–derived macrophagealternatively activated macrophageclassically activated macrophageAlternatively activated macrophagestype 2 innate lymphoid cellwild-typeInducible costimulator
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Authors
Dong PhD, Rodrigo PhD, Anne-Gaëlle PhD, Mousa PhD, Majid S. MSc, Li BSc, Gerard J. PhD, Mariola PhD, Foo Y. PhD, Charles PhD, Damo PhD,