Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6065942 | Journal of Allergy and Clinical Immunology | 2013 | 18 Pages |
Abstract
A short-term mouse model of cigarette smoke-induced COPD was developed in which the characteristic features of the disease were induced more rapidly than in existing models. The model can be used to better understand COPD pathogenesis, and we show a requirement for macrophages and tryptase-expressing MCs.
Keywords
qPCRFRCmMCPTLCFVCC57BL/6Quantitative PCREmphysemainflammationAirway remodelingBALFChronic obstructive pulmonary diseaseCOPDCigarette smokeFunctional residual capacityforced vital capacityTotal lung capacityLung functionMast cellMacrophageBronchoalveolar lavage fluidwild-typeProteasemouse mast cell protease
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Authors
Emma L. B Biomed Sci, Richard L. PhD, Andrew G. PhD, Richard Y. B Biomed Sci, Irwan BSc, Nicole G. PhD, Andrew BSc, Simon PhD, Jay C. PhD, Ming MD, PhD, Brian G. PhD, Nico PhD, Mark D. MD, PhD, Roberto MD, Roy J. MD, Sahar Hamadi, Peter A. MD, PhD,