| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6066114 | Journal of Allergy and Clinical Immunology | 2014 | 8 Pages |
Abstract
IL33-IL1RL1 pathway polymorphisms are associated with asthma and specific wheezing phenotypes; that is, most SNPs are associated with intermediate-onset wheeze, a phenotype closely associated with sensitization. We speculate that IL33-IL1RL1 pathway polymorphisms affect development of wheeze and subsequent asthma through sensitization in early childhood.
Keywords
IL-1 receptor–like 1wheezing phenotypesPIAMAIL33TIRAPGWAIRAK4ALSPACTRAF6eQTLIRAK1MYD88IL1RL1AsthmaAvon Longitudinal Study of Parents and ChildrenGenome-wide associationExpression quantitative trait locusTIRLinkage disequilibriummyeloid differentiation primary response gene 88IL-1 receptor accessory proteinSingle nucleotide polymorphismSNPChildren
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Authors
Olga E. MD, Jestinah M. PhD, Raquel PhD, Marjan MD, PhD, F. Nicole MD, Johan C. MD, PhD, Henriëtte A. PhD, Bert PhD, Dirkje S. MD, PhD, Kristel PhD, John MD, PhD, Gerard H. MD, PhD,