| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6066121 | Journal of Allergy and Clinical Immunology | 2014 | 13 Pages |
Abstract
Our results indicate that miR-150 is a common posttranscriptional regulator for Prf1 in mouse and human NK cells that represses NK cell lytic activity. Thus the therapeutic control of miR-150 in NK cells could enhance NK cell-based immunotherapy against cancer, providing a better clinical outcome.
Keywords
DMEMEffector/targetAralkylamine N-acetyltransferaseGZMBNeoRNK cell cytotoxicityGranzyme BPRF1Dulbecco Modified Eagle MediumGAPDHHEKnatural killerE/TimmunotherapymiR-150NK cellsAANATPost-transcriptional regulationUTR یا untranslated regions untranslated regionMicroRNAMiRNAwild-typePropidium iodideNeomycin resistance genehuman embryonic kidneyglyceraldehyde-3-phosphate dehydrogenase
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Authors
Nayoung PhD, Miju PhD, Sohyun PhD, Junsang PhD, Philip D. MD, Tae-Don PhD, Inpyo PhD,