CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation

These findings suggest that regardless of the underlying disease, the presence of CXCR4+/IgG+ PCs in the gut is a strong yet localized indicator of intestinal inflammation. Furthermore, our findings suggest that CXCR4+/IgG+ PCs might play a role in immune cell homeostasis during inflammatory processes of the gut.