| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6066466 | Journal of Allergy and Clinical Immunology | 2013 | 9 Pages |
Abstract
The stratum corneum of lesional but also clinically unaffected skin of adults with AD is abnormal, with reduced expression of FLG and FLG-like proteins. In addition to nonsense mutations, proinflammatory cytokines and some defects in the proFLG processing can contribute to the FLG downregulation. Our study suggests that skin inflammation reduces the expression of FLG-like proteins, contributing to the AD-related epidermal barrier dysfunction.
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Authors
Laurence PhD, Julie PhD, Chiung-Yueh PhD, Stéfana MD, Catherine PhD, Marie-Claire PhD, Britta PhD, Elke PhD, Stefan MD, PhD, Anne-Marie MD, PhD, Guy MD, PhD, Carle MD, PhD, Michel PhD,