| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6066776 | Journal of Allergy and Clinical Immunology | 2012 | 15 Pages |
Abstract
Rhinovirus induction of type I interferons in BAL cells is delayed and deficient and might be a marker of more severe asthma. Defective rhinovirus interferon induction in asthmatic patients was not accompanied by differences in the expression or induction of key molecules implicated in viral induction of interferons.
Keywords
retinoic acid–inducible gene IHBECIkkBCARDIFRIG-IIRFdsRNAMDA-5IRAK4bronchoalveolar lavage cellsPRRTLRRhinovirus 16BALMYD88IκB kinase βdouble-stranded RNATRIFAsthmainterferonToll-like receptorcaspase recruitment domainHuman bronchial epithelial cellperipheral blood mononuclear cellsinterferon regulatory factorbronchoalveolar lavageRhinovirusAirway hyperresponsivenessmyeloid differentiation primary response gene (88)CARDPattern-recognition receptor
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Authors
Annemarie MD, PhD, Michael R. PhD, Jonathan MD, BSc, Ajerico BSc, Eteri MSc, Maria-Belen BSc, Onn Min MD, PhD, Patrick MD, PhD, Mark PhD, Sebastian L. MD, PhD,