| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6066793 | Journal of Allergy and Clinical Immunology | 2012 | 13 Pages |
Abstract
This study demonstrates a direct interaction of HLA with drugs, provides a detailed molecular mechanism of HLA-associated drug hypersensitivity, and has clinical correlations for CBZ-related drug-induced SJS/TEN.
Keywords
MCSSCarbamazepine 10,11-epoxideCTLOXCCbzESLTCrAPCSJSLTTTCLB-LCLHSsAEDLICantigen-presenting cellHLAEslicarbazepine acetateOxcarbazepinelymphocyte transformation testSurface plasmon resonanceSPRDrug hypersensitivityT-cell lineantiepileptic drugtenStevens-Johnson syndromehypersensitivity syndromecytotoxic T lymphocyteToxic epidermal necrolysiscarbamazepineT-cell receptor
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Authors
Chun-Yu MS, Wen-Hung MD, PhD, Hsiao-Wen MS, Yuan-Tsong MD, PhD, Shuen-Iu PhD,