| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6066821 | Journal of Allergy and Clinical Immunology | 2012 | 10 Pages |
Abstract
The presence of CRACM channels, a CRACM-like current, and functional inhibition of HLMC Ca2+ influx, mediator release, and allergen-induced bronchial smooth muscle contraction by CRACM-channel blockers supports a role for CRACM channels in FcεRI-dependent HLMC secretion. CRACM channels are therefore a potential therapeutic target in the treatment of asthma and related allergic diseases.
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Authors
Ian PhD, S. Mark PhD, Mark L. PhD, Valerie S. BSc, Malcolm PhD, Peter DM,