Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6066898 | Journal of Allergy and Clinical Immunology | 2012 | 13 Pages |
Abstract
Dendritic cells (DCs) are known to play a central role in sensing the presence of foreign antigens and infectious agents and in initiating appropriate immune responses. More recently, an additional role has been discovered for DCs in determining whether the response to potential environmental allergens will be one of tolerance or whether a vigorous response along allergic pathways will be initiated. This review discusses ways in which DCs participate specifically in initiating allergic responses, particularly those associated with allergic asthma, and how interventions focused on DCs might lead to new therapeutic approaches to asthma.
Keywords
IDOCDCPDCOX40LTH2 inflammationHDMBDCATSLPTLRMMP-9MDCOVAAsthmaAllergenBlood dendritic cell antigenOvalbuminindoleamine 2,3-dioxygenaseBALFthymus and activation-regulated chemokineParToll-like receptorTARCDendritic cellPlasmacytoid dendritic cellconventional dendritic cellDendritic cellsMyeloid dendritic cellTRAILThymic stromal lymphopoietinOX40 ligandTNF-related apoptosis-inducing ligandMatrix metalloproteinase 9Bronchoalveolar lavage fluidwild-typeSignal regulatory protein αHouse dust miteprotease-activated receptor
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Authors
Michelle Ann MD, PhD,